Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia
Identifieur interne : 003759 ( Main/Exploration ); précédent : 003758; suivant : 003760Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia
Auteurs : Edwin D. Hawkins [Australie] ; Jane Oliaro [Australie] ; Kelly M. Ramsbottom [Australie] ; Stephen B. Ting [Australie] ; Faruk Sacirbegovic [Australie] ; Michael Harvey [Australie] ; Tanja Kinwell [Australie] ; Jacques Ghysdael [France] ; Ricky W. Johnstone [Australie] ; Patrick O. Humbert [Australie] ; Sarah M. Russell [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Amorces ADN (génétique), Animaux, Cellules souches hématopoïétiques (métabolisme), Estimation de Kaplan-Meier, Leucémie B (métabolisme), Leucémie à cellules T (métabolisme), Lignage cellulaire (physiologie), Modèles animaux de maladie humaine, Protéines suppresseurs de tumeurs (génétique), Protéines suppresseurs de tumeurs (métabolisme), Protéines à homéodomaine (génétique), Protéines à homéodomaine (métabolisme), RT-PCR, Réaction de polymérisation en chaine en temps réel, Souris, Souris knockout, Transplantation de moelle osseuse.
- MESH :
- génétique : Amorces ADN, Protéines suppresseurs de tumeurs, Protéines à homéodomaine.
- métabolisme : Cellules souches hématopoïétiques, Leucémie B, Leucémie à cellules T, Protéines suppresseurs de tumeurs, Protéines à homéodomaine.
- physiologie : Lignage cellulaire.
- Animaux, Estimation de Kaplan-Meier, Modèles animaux de maladie humaine, RT-PCR, Réaction de polymérisation en chaine en temps réel, Souris, Souris knockout, Transplantation de moelle osseuse.
English descriptors
- KwdEn :
- Animals, Bone Marrow Transplantation, Cell Lineage (physiology), DNA Primers (genetics), Disease Models, Animal, Hematopoietic Stem Cells (metabolism), Homeodomain Proteins (genetics), Homeodomain Proteins (metabolism), Kaplan-Meier Estimate, Leukemia, B-Cell (metabolism), Leukemia, T-Cell (metabolism), Mice, Mice, Knockout, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins (genetics), Tumor Suppressor Proteins (metabolism).
- MESH :
- chemical , genetics : DNA Primers, Homeodomain Proteins, Tumor Suppressor Proteins.
- metabolism : Hematopoietic Stem Cells, Homeodomain Proteins, Leukemia, B-Cell, Leukemia, T-Cell, Tumor Suppressor Proteins.
- physiology : Cell Lineage.
- Animals, Bone Marrow Transplantation, Disease Models, Animal, Kaplan-Meier Estimate, Mice, Mice, Knockout, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
In epithelial and stem cells, lethal giant larvae (Lgl) is a potent tumour suppressor, a regulator of Notch signalling, and a mediator of cell fate via asymmetric cell division. Recent evidence suggests that the function of Lgl is conserved in mammalian haematopoietic stem cells and implies a contribution to haematological malignancies. To date, direct measurement of the effect of Lgl expression on malignancies of the haematopoietic lineage has not been tested. In Lgl1−/− mice, we analysed the development of haematopoietic malignancies either alone, or in the presence of common oncogenic lesions. We show that in the absence of Lgl1, production of mature white blood cell lineages and long-term survival of mice are not affected. Additionally, loss of Lgl1 does not alter leukaemia driven by constitutive Notch, c-Myc or Jak2 signalling. These results suggest that the role of Lgl1 in the haematopoietic lineage might be restricted to specific co-operating mutations and a limited number of cellular contexts.
Url:
DOI: 10.1371/journal.pone.0087376
PubMed: 24475281
PubMed Central: 3903681
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002B44
- to stream Pmc, to step Curation: 002994
- to stream Pmc, to step Checkpoint: 001491
- to stream PubMed, to step Corpus: 003988
- to stream PubMed, to step Curation: 003872
- to stream PubMed, to step Checkpoint: 003872
- to stream Ncbi, to step Merge: 001753
- to stream Ncbi, to step Curation: 001753
- to stream Ncbi, to step Checkpoint: 001753
- to stream Main, to step Merge: 003786
- to stream Main, to step Curation: 003759
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia</title>
<author><name sortKey="Hawkins, Edwin D" sort="Hawkins, Edwin D" uniqKey="Hawkins E" first="Edwin D." last="Hawkins">Edwin D. Hawkins</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramsbottom, Kelly M" sort="Ramsbottom, Kelly M" uniqKey="Ramsbottom K" first="Kelly M." last="Ramsbottom">Kelly M. Ramsbottom</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ting, Stephen B" sort="Ting, Stephen B" uniqKey="Ting S" first="Stephen B." last="Ting">Stephen B. Ting</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Stem Cell Research Group, Australian Centre for Blood Diseases, Monash University and Alfred Health, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stem Cell Research Group, Australian Centre for Blood Diseases, Monash University and Alfred Health, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sacirbegovic, Faruk" sort="Sacirbegovic, Faruk" uniqKey="Sacirbegovic F" first="Faruk" last="Sacirbegovic">Faruk Sacirbegovic</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harvey, Michael" sort="Harvey, Michael" uniqKey="Harvey M" first="Michael" last="Harvey">Michael Harvey</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kinwell, Tanja" sort="Kinwell, Tanja" uniqKey="Kinwell T" first="Tanja" last="Kinwell">Tanja Kinwell</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Institut Curie, Centre Universitaire, Bat 110 91405, Orsay, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Centre Universitaire, Bat 110 91405, Orsay</wicri:regionArea>
<wicri:noRegion>91405, Orsay</wicri:noRegion>
<wicri:noRegion>91405, Orsay</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Centre National de la Recherche Scientifique UMR 3306, Orsay, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique UMR 3306, Orsay</wicri:regionArea>
<placeName><settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>INSERM (Institut National de la Santé et de la Recherche Médicale) U1005, Orsay, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM (Institut National de la Santé et de la Recherche Médicale) U1005, Orsay</wicri:regionArea>
<placeName><settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnstone, Ricky W" sort="Johnstone, Ricky W" uniqKey="Johnstone R" first="Ricky W." last="Johnstone">Ricky W. Johnstone</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Humbert, Patrick O" sort="Humbert, Patrick O" uniqKey="Humbert P" first="Patrick O." last="Humbert">Patrick O. Humbert</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Russell, Sarah M" sort="Russell, Sarah M" uniqKey="Russell S" first="Sarah M." last="Russell">Sarah M. Russell</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24475281</idno>
<idno type="pmc">3903681</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903681</idno>
<idno type="RBID">PMC:3903681</idno>
<idno type="doi">10.1371/journal.pone.0087376</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">002B44</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B44</idno>
<idno type="wicri:Area/Pmc/Curation">002994</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002994</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001491</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001491</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003988</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003988</idno>
<idno type="wicri:Area/PubMed/Curation">003872</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003872</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003872</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003872</idno>
<idno type="wicri:Area/Ncbi/Merge">001753</idno>
<idno type="wicri:Area/Ncbi/Curation">001753</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001753</idno>
<idno type="wicri:Area/Main/Merge">003786</idno>
<idno type="wicri:Area/Main/Curation">003759</idno>
<idno type="wicri:Area/Main/Exploration">003759</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia</title>
<author><name sortKey="Hawkins, Edwin D" sort="Hawkins, Edwin D" uniqKey="Hawkins E" first="Edwin D." last="Hawkins">Edwin D. Hawkins</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ramsbottom, Kelly M" sort="Ramsbottom, Kelly M" uniqKey="Ramsbottom K" first="Kelly M." last="Ramsbottom">Kelly M. Ramsbottom</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ting, Stephen B" sort="Ting, Stephen B" uniqKey="Ting S" first="Stephen B." last="Ting">Stephen B. Ting</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Stem Cell Research Group, Australian Centre for Blood Diseases, Monash University and Alfred Health, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stem Cell Research Group, Australian Centre for Blood Diseases, Monash University and Alfred Health, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sacirbegovic, Faruk" sort="Sacirbegovic, Faruk" uniqKey="Sacirbegovic F" first="Faruk" last="Sacirbegovic">Faruk Sacirbegovic</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harvey, Michael" sort="Harvey, Michael" uniqKey="Harvey M" first="Michael" last="Harvey">Michael Harvey</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kinwell, Tanja" sort="Kinwell, Tanja" uniqKey="Kinwell T" first="Tanja" last="Kinwell">Tanja Kinwell</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Institut Curie, Centre Universitaire, Bat 110 91405, Orsay, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Centre Universitaire, Bat 110 91405, Orsay</wicri:regionArea>
<wicri:noRegion>91405, Orsay</wicri:noRegion>
<wicri:noRegion>91405, Orsay</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Centre National de la Recherche Scientifique UMR 3306, Orsay, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique UMR 3306, Orsay</wicri:regionArea>
<placeName><settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>INSERM (Institut National de la Santé et de la Recherche Médicale) U1005, Orsay, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM (Institut National de la Santé et de la Recherche Médicale) U1005, Orsay</wicri:regionArea>
<placeName><settlement type="city">Orsay</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnstone, Ricky W" sort="Johnstone, Ricky W" uniqKey="Johnstone R" first="Ricky W." last="Johnstone">Ricky W. Johnstone</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Humbert, Patrick O" sort="Humbert, Patrick O" uniqKey="Humbert P" first="Patrick O." last="Humbert">Patrick O. Humbert</name>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Russell, Sarah M" sort="Russell, Sarah M" uniqKey="Russell S" first="Sarah M." last="Russell">Sarah M. Russell</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Bone Marrow Transplantation</term>
<term>Cell Lineage (physiology)</term>
<term>DNA Primers (genetics)</term>
<term>Disease Models, Animal</term>
<term>Hematopoietic Stem Cells (metabolism)</term>
<term>Homeodomain Proteins (genetics)</term>
<term>Homeodomain Proteins (metabolism)</term>
<term>Kaplan-Meier Estimate</term>
<term>Leukemia, B-Cell (metabolism)</term>
<term>Leukemia, T-Cell (metabolism)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Tumor Suppressor Proteins (genetics)</term>
<term>Tumor Suppressor Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Amorces ADN (génétique)</term>
<term>Animaux</term>
<term>Cellules souches hématopoïétiques (métabolisme)</term>
<term>Estimation de Kaplan-Meier</term>
<term>Leucémie B (métabolisme)</term>
<term>Leucémie à cellules T (métabolisme)</term>
<term>Lignage cellulaire (physiologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Protéines suppresseurs de tumeurs (génétique)</term>
<term>Protéines suppresseurs de tumeurs (métabolisme)</term>
<term>Protéines à homéodomaine (génétique)</term>
<term>Protéines à homéodomaine (métabolisme)</term>
<term>RT-PCR</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Transplantation de moelle osseuse</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Primers</term>
<term>Homeodomain Proteins</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Amorces ADN</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Protéines à homéodomaine</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hematopoietic Stem Cells</term>
<term>Homeodomain Proteins</term>
<term>Leukemia, B-Cell</term>
<term>Leukemia, T-Cell</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules souches hématopoïétiques</term>
<term>Leucémie B</term>
<term>Leucémie à cellules T</term>
<term>Protéines suppresseurs de tumeurs</term>
<term>Protéines à homéodomaine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lignage cellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Lineage</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Bone Marrow Transplantation</term>
<term>Disease Models, Animal</term>
<term>Kaplan-Meier Estimate</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Real-Time Polymerase Chain Reaction</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Estimation de Kaplan-Meier</term>
<term>Modèles animaux de maladie humaine</term>
<term>RT-PCR</term>
<term>Réaction de polymérisation en chaine en temps réel</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Transplantation de moelle osseuse</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>In epithelial and stem cells, lethal giant larvae (Lgl) is a potent tumour suppressor, a regulator of Notch signalling, and a mediator of cell fate via asymmetric cell division. Recent evidence suggests that the function of Lgl is conserved in mammalian haematopoietic stem cells and implies a contribution to haematological malignancies. To date, direct measurement of the effect of Lgl expression on malignancies of the haematopoietic lineage has not been tested. In Lgl1<sup>−/−</sup>
mice, we analysed the development of haematopoietic malignancies either alone, or in the presence of common oncogenic lesions. We show that in the absence of Lgl1, production of mature white blood cell lineages and long-term survival of mice are not affected. Additionally, loss of Lgl1 does not alter leukaemia driven by constitutive Notch, c-Myc or Jak2 signalling. These results suggest that the role of Lgl1 in the haematopoietic lineage might be restricted to specific co-operating mutations and a limited number of cellular contexts.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Betschinger, J" uniqKey="Betschinger J">J Betschinger</name>
</author>
<author><name sortKey="Mechtler, K" uniqKey="Mechtler K">K Mechtler</name>
</author>
<author><name sortKey="Knoblich, Ja" uniqKey="Knoblich J">JA Knoblich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Cy" uniqKey="Lee C">CY Lee</name>
</author>
<author><name sortKey="Robinson, Kj" uniqKey="Robinson K">KJ Robinson</name>
</author>
<author><name sortKey="Doe, Cq" uniqKey="Doe C">CQ Doe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wirtz Peitz, F" uniqKey="Wirtz Peitz F">F Wirtz-Peitz</name>
</author>
<author><name sortKey="Nishimura, T" uniqKey="Nishimura T">T Nishimura</name>
</author>
<author><name sortKey="Knoblich, Ja" uniqKey="Knoblich J">JA Knoblich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bilder, D" uniqKey="Bilder D">D Bilder</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
<author><name sortKey="Perrimon, N" uniqKey="Perrimon N">N Perrimon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Humbert, Po" uniqKey="Humbert P">PO Humbert</name>
</author>
<author><name sortKey="Grzeschik, Na" uniqKey="Grzeschik N">NA Grzeschik</name>
</author>
<author><name sortKey="Brumby, Am" uniqKey="Brumby A">AM Brumby</name>
</author>
<author><name sortKey="Galea, R" uniqKey="Galea R">R Galea</name>
</author>
<author><name sortKey="Elsum, I" uniqKey="Elsum I">I Elsum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klezovitch, O" uniqKey="Klezovitch O">O Klezovitch</name>
</author>
<author><name sortKey="Fernandez, Te" uniqKey="Fernandez T">TE Fernandez</name>
</author>
<author><name sortKey="Tapscott, Sj" uniqKey="Tapscott S">SJ Tapscott</name>
</author>
<author><name sortKey="Vasioukhin, V" uniqKey="Vasioukhin V">V Vasioukhin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grifoni, D" uniqKey="Grifoni D">D Grifoni</name>
</author>
<author><name sortKey="Garoia, F" uniqKey="Garoia F">F Garoia</name>
</author>
<author><name sortKey="Schimanski, Cc" uniqKey="Schimanski C">CC Schimanski</name>
</author>
<author><name sortKey="Schmitz, G" uniqKey="Schmitz G">G Schmitz</name>
</author>
<author><name sortKey="Laurenti, E" uniqKey="Laurenti E">E Laurenti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Korshunov, A" uniqKey="Korshunov A">A Korshunov</name>
</author>
<author><name sortKey="Sycheva, R" uniqKey="Sycheva R">R Sycheva</name>
</author>
<author><name sortKey="Golanov, A" uniqKey="Golanov A">A Golanov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuphal, S" uniqKey="Kuphal S">S Kuphal</name>
</author>
<author><name sortKey="Wallner, S" uniqKey="Wallner S">S Wallner</name>
</author>
<author><name sortKey="Schimanski, Cc" uniqKey="Schimanski C">CC Schimanski</name>
</author>
<author><name sortKey="Bataille, F" uniqKey="Bataille F">F Bataille</name>
</author>
<author><name sortKey="Hofer, P" uniqKey="Hofer P">P Hofer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schimanski, Cc" uniqKey="Schimanski C">CC Schimanski</name>
</author>
<author><name sortKey="Schmitz, G" uniqKey="Schmitz G">G Schmitz</name>
</author>
<author><name sortKey="Kashyap, A" uniqKey="Kashyap A">A Kashyap</name>
</author>
<author><name sortKey="Bosserhoff, Ak" uniqKey="Bosserhoff A">AK Bosserhoff</name>
</author>
<author><name sortKey="Bataille, F" uniqKey="Bataille F">F Bataille</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pajcini, Kv" uniqKey="Pajcini K">KV Pajcini</name>
</author>
<author><name sortKey="Speck, Na" uniqKey="Speck N">NA Speck</name>
</author>
<author><name sortKey="Pear, Ws" uniqKey="Pear W">WS Pear</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stier, S" uniqKey="Stier S">S Stier</name>
</author>
<author><name sortKey="Cheng, T" uniqKey="Cheng T">T Cheng</name>
</author>
<author><name sortKey="Dombkowski, D" uniqKey="Dombkowski D">D Dombkowski</name>
</author>
<author><name sortKey="Carlesso, N" uniqKey="Carlesso N">N Carlesso</name>
</author>
<author><name sortKey="Scadden, Dt" uniqKey="Scadden D">DT Scadden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, M" uniqKey="Wu M">M Wu</name>
</author>
<author><name sortKey="Kwon, Hy" uniqKey="Kwon H">HY Kwon</name>
</author>
<author><name sortKey="Rattis, F" uniqKey="Rattis F">F Rattis</name>
</author>
<author><name sortKey="Blum, J" uniqKey="Blum J">J Blum</name>
</author>
<author><name sortKey="Zhao, C" uniqKey="Zhao C">C Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weng, Ap" uniqKey="Weng A">AP Weng</name>
</author>
<author><name sortKey="Ferrando, Aa" uniqKey="Ferrando A">AA Ferrando</name>
</author>
<author><name sortKey="Lee, W" uniqKey="Lee W">W Lee</name>
</author>
<author><name sortKey="Morris, Jp" uniqKey="Morris J">JP Morris</name>
</author>
<author><name sortKey="Silverman, Lb" uniqKey="Silverman L">LB Silverman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Heidel, Fh" uniqKey="Heidel F">FH Heidel</name>
</author>
<author><name sortKey="Bullinger, L" uniqKey="Bullinger L">L Bullinger</name>
</author>
<author><name sortKey="Arreba Tutusaus, P" uniqKey="Arreba Tutusaus P">P Arreba-Tutusaus</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Gaebel, J" uniqKey="Gaebel J">J Gaebel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beekman, R" uniqKey="Beekman R">R Beekman</name>
</author>
<author><name sortKey="Valkhof, Mg" uniqKey="Valkhof M">MG Valkhof</name>
</author>
<author><name sortKey="Sanders, Ma" uniqKey="Sanders M">MA Sanders</name>
</author>
<author><name sortKey="Van Strien, Pm" uniqKey="Van Strien P">PM van Strien</name>
</author>
<author><name sortKey="Haanstra, Jr" uniqKey="Haanstra J">JR Haanstra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kelly, Pn" uniqKey="Kelly P">PN Kelly</name>
</author>
<author><name sortKey="Puthalakath, H" uniqKey="Puthalakath H">H Puthalakath</name>
</author>
<author><name sortKey="Adams, Jm" uniqKey="Adams J">JM Adams</name>
</author>
<author><name sortKey="Strasser, A" uniqKey="Strasser A">A Strasser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aster, Jc" uniqKey="Aster J">JC Aster</name>
</author>
<author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name>
</author>
<author><name sortKey="Karnell, Fg" uniqKey="Karnell F">FG Karnell</name>
</author>
<author><name sortKey="Patriub, V" uniqKey="Patriub V">V Patriub</name>
</author>
<author><name sortKey="Pui, Jc" uniqKey="Pui J">JC Pui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pear, Ws" uniqKey="Pear W">WS Pear</name>
</author>
<author><name sortKey="Nolan, Gp" uniqKey="Nolan G">GP Nolan</name>
</author>
<author><name sortKey="Scott, Ml" uniqKey="Scott M">ML Scott</name>
</author>
<author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hagn, M" uniqKey="Hagn M">M Hagn</name>
</author>
<author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name>
</author>
<author><name sortKey="Kallies, A" uniqKey="Kallies A">A Kallies</name>
</author>
<author><name sortKey="Sutton, Vr" uniqKey="Sutton V">VR Sutton</name>
</author>
<author><name sortKey="Thia, Ky" uniqKey="Thia K">KY Thia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hawkins, Ed" uniqKey="Hawkins E">ED Hawkins</name>
</author>
<author><name sortKey="Oliaro, J" uniqKey="Oliaro J">J Oliaro</name>
</author>
<author><name sortKey="Kallies, A" uniqKey="Kallies A">A Kallies</name>
</author>
<author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name>
</author>
<author><name sortKey="Filby, A" uniqKey="Filby A">A Filby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hawkins, Ed" uniqKey="Hawkins E">ED Hawkins</name>
</author>
<author><name sortKey="Russell, Sm" uniqKey="Russell S">SM Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harris, Aw" uniqKey="Harris A">AW Harris</name>
</author>
<author><name sortKey="Pinkert, Ca" uniqKey="Pinkert C">CA Pinkert</name>
</author>
<author><name sortKey="Crawford, M" uniqKey="Crawford M">M Crawford</name>
</author>
<author><name sortKey="Langdon, Wy" uniqKey="Langdon W">WY Langdon</name>
</author>
<author><name sortKey="Brinster, Rl" uniqKey="Brinster R">RL Brinster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carron, C" uniqKey="Carron C">C Carron</name>
</author>
<author><name sortKey="Cormier, F" uniqKey="Cormier F">F Cormier</name>
</author>
<author><name sortKey="Janin, A" uniqKey="Janin A">A Janin</name>
</author>
<author><name sortKey="Lacronique, V" uniqKey="Lacronique V">V Lacronique</name>
</author>
<author><name sortKey="Giovannini, M" uniqKey="Giovannini M">M Giovannini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sripathy, S" uniqKey="Sripathy S">S Sripathy</name>
</author>
<author><name sortKey="Lee, M" uniqKey="Lee M">M Lee</name>
</author>
<author><name sortKey="Vasioukhin, V" uniqKey="Vasioukhin V">V Vasioukhin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eppert, K" uniqKey="Eppert K">K Eppert</name>
</author>
<author><name sortKey="Takenaka, K" uniqKey="Takenaka K">K Takenaka</name>
</author>
<author><name sortKey="Lechman, Er" uniqKey="Lechman E">ER Lechman</name>
</author>
<author><name sortKey="Waldron, L" uniqKey="Waldron L">L Waldron</name>
</author>
<author><name sortKey="Nilsson, B" uniqKey="Nilsson B">B Nilsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sengupta, A" uniqKey="Sengupta A">A Sengupta</name>
</author>
<author><name sortKey="Duran, A" uniqKey="Duran A">A Duran</name>
</author>
<author><name sortKey="Ishikawa, E" uniqKey="Ishikawa E">E Ishikawa</name>
</author>
<author><name sortKey="Florian, Mc" uniqKey="Florian M">MC Florian</name>
</author>
<author><name sortKey="Dunn, Sk" uniqKey="Dunn S">SK Dunn</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
</country>
<region><li>Victoria (État)</li>
</region>
<settlement><li>Melbourne</li>
<li>Orsay</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Hawkins, Edwin D" sort="Hawkins, Edwin D" uniqKey="Hawkins E" first="Edwin D." last="Hawkins">Edwin D. Hawkins</name>
</noRegion>
<name sortKey="Harvey, Michael" sort="Harvey, Michael" uniqKey="Harvey M" first="Michael" last="Harvey">Michael Harvey</name>
<name sortKey="Harvey, Michael" sort="Harvey, Michael" uniqKey="Harvey M" first="Michael" last="Harvey">Michael Harvey</name>
<name sortKey="Hawkins, Edwin D" sort="Hawkins, Edwin D" uniqKey="Hawkins E" first="Edwin D." last="Hawkins">Edwin D. Hawkins</name>
<name sortKey="Humbert, Patrick O" sort="Humbert, Patrick O" uniqKey="Humbert P" first="Patrick O." last="Humbert">Patrick O. Humbert</name>
<name sortKey="Humbert, Patrick O" sort="Humbert, Patrick O" uniqKey="Humbert P" first="Patrick O." last="Humbert">Patrick O. Humbert</name>
<name sortKey="Johnstone, Ricky W" sort="Johnstone, Ricky W" uniqKey="Johnstone R" first="Ricky W." last="Johnstone">Ricky W. Johnstone</name>
<name sortKey="Johnstone, Ricky W" sort="Johnstone, Ricky W" uniqKey="Johnstone R" first="Ricky W." last="Johnstone">Ricky W. Johnstone</name>
<name sortKey="Kinwell, Tanja" sort="Kinwell, Tanja" uniqKey="Kinwell T" first="Tanja" last="Kinwell">Tanja Kinwell</name>
<name sortKey="Kinwell, Tanja" sort="Kinwell, Tanja" uniqKey="Kinwell T" first="Tanja" last="Kinwell">Tanja Kinwell</name>
<name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name>
<name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name>
<name sortKey="Ramsbottom, Kelly M" sort="Ramsbottom, Kelly M" uniqKey="Ramsbottom K" first="Kelly M." last="Ramsbottom">Kelly M. Ramsbottom</name>
<name sortKey="Ramsbottom, Kelly M" sort="Ramsbottom, Kelly M" uniqKey="Ramsbottom K" first="Kelly M." last="Ramsbottom">Kelly M. Ramsbottom</name>
<name sortKey="Russell, Sarah M" sort="Russell, Sarah M" uniqKey="Russell S" first="Sarah M." last="Russell">Sarah M. Russell</name>
<name sortKey="Russell, Sarah M" sort="Russell, Sarah M" uniqKey="Russell S" first="Sarah M." last="Russell">Sarah M. Russell</name>
<name sortKey="Russell, Sarah M" sort="Russell, Sarah M" uniqKey="Russell S" first="Sarah M." last="Russell">Sarah M. Russell</name>
<name sortKey="Sacirbegovic, Faruk" sort="Sacirbegovic, Faruk" uniqKey="Sacirbegovic F" first="Faruk" last="Sacirbegovic">Faruk Sacirbegovic</name>
<name sortKey="Sacirbegovic, Faruk" sort="Sacirbegovic, Faruk" uniqKey="Sacirbegovic F" first="Faruk" last="Sacirbegovic">Faruk Sacirbegovic</name>
<name sortKey="Ting, Stephen B" sort="Ting, Stephen B" uniqKey="Ting S" first="Stephen B." last="Ting">Stephen B. Ting</name>
</country>
<country name="France"><noRegion><name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
</noRegion>
<name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
<name sortKey="Ghysdael, Jacques" sort="Ghysdael, Jacques" uniqKey="Ghysdael J" first="Jacques" last="Ghysdael">Jacques Ghysdael</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003759 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003759 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3903681 |texte= Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24475281" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |